치주 조직 재생과 캐리어를 위한 다양한 합성골 이식재의 개발과 평가
Development and Evaluation of Synthetic Bone Graft Materials for Periodontal Tissue Regeneration and Carriers
김유경, 유훈, 임현창, 이중석, 정의원, 이용근, 최성호,
소속 상세정보
김유경 ( Kim You-Kyoung ) - 연세대학교 치과대학 치주과학교실
유훈 ( You Hoon ) - 연세대학교 치과대학 치주과학교실
임현창 ( Lim Hyun-Chang ) - 연세대학교 치과대학 치주과학교실
이중석 ( Lee Jung-Seok ) - 연세대학교 치과대학 치주과학교실
정의원 ( Jung Ui-Won ) - 연세대학교 치과대학 치주과학교실
이용근 ( Lee Yong-Keun ) - 조선대학교 치과대학 노인구강질환제어연구센터
최성호 ( Choi Seong-Ho ) - 연세대학교 치과대학 치주과학교실
KMID : 0602720140180040246
Abstract
Purpose: The aim of this study was to evaluate the enhanced biocompatibility and mechanical properties of various newly developed carriers and osteoconductivity of bone graft materials in several studies conducted at Department of Periodontology, Yonsei University College of Dentistry, Seoul, Korea.
Materials and Methods: Studies were performed divided into the following two different subjects. 1) Development and evaluation of mechanical strength, biocompatibility and drug release capacity of new carriers: gelatin-layered and multi-sized porous β-tricalcium phosphate (β-TCP), hollow hydroxyapatite spherical granules and porous calcium polyphosphate granules. 2) Evaluation of bone regeneration of various particlulated bone graft materials: alloplast (demineralized bone matrix [DBM] gel), xenoplast (bovine bone), synthetic bone (hydroxyapatite, β-TCP, biphasic calcium phosphate [BCP]) and block bone graft materials: nano-hydroxyapatite block bone and bovine hydroxyapatite/collagen block.
Results: Gelatin-coated multi-sized porous β-TCP showed enhanced compressive strength and affected cell viability and differentiation. Penetrability of drugs can be controlled by change of structure and pore properties of hollow hydroxyapatite spherical granules. Pore size and porosity of porous calcium phosphate influenced the osteogenic differentiation and cell differentiation. Even though limited volume stability of DBM gel was observed, bone regeneration of various graft materials was not significantly different. In particular, superior new bone formation in BCP and large resorption of β-TCP was observed among various calcium phosphate materials (hydroxyapatite, β-TCP and BCP). Block bone graft materials had better stability and space-maintaining capacity in one wall intrabony defects.
Conclusion: With the potentials and limitations of the suggested list of studies, effective carriers and various bone graft materials can be used for better periodontal regeneration in aspect of enhanced osteogenic properties and further studies are required for proper selection and application of materials in various intrabony defects.
키워드
biphasic calcium phosphate; block bone graft; carrier; hydroxyapatite; osteoconductivity; tissue engineering
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